Stupid Never Dies is a roguelike action game that sees you take on the role of Davy, a zombie who's sentenced to roam his local mall eternally, until a mad scientist recruits you to go down a magical toilet, battle demons, and reverse a world-ending calamity. The gameplay loop involves descending layers of an underground labyrinth, taking down enemies, and completing objectives to progress. Each run is timed, and if you run out of time, you're sent back to the beginning.

The combat is generic, but the game offers a wide range of options, making it difficult to lock into a build. Davy can consume elite enemies and turn into them, gaining new abilities. The game also features a 'Stupid Parry' that feels like a parry for the sake of having one, and the ability to bite enemies to regain health. The upgrades are so fractional that players may not notice a difference if they ignore this element of the game completely.